12 best Panama Canal cruises for a bucket-list trip

A Panama Canal transit is a rite of passage for many cruise lovers. Experiencing this marvel of early 20th-century engineering appeals to those with a wide array of interests, from history and politics to colonial architecture and wildlife. Built by the U.S. government between 1903 and 1914, this 50-mile waterway linking the Atlantic and Pacific oceans revolutionized shipping by creating an expedited route for the transportation of cargo and, ultimately, cruise ship passengers.

Panama Canal itineraries are offered by almost every cruise line. Thanks to a 2016 canal expansion project, a third set of locks can now accommodate larger vessels. It’s possible to cruise the Panama Canal on ships of all sizes (from 148 guests to more than 3,000), on itineraries that range from a week in the sun to a six-month world cruise.

Some ships sail a full transit of the canal, from the Atlantic to the Pacific or vice versa. These one-way journeys between Miami or Fort Lauderdale and Los Angeles or San Diego visit ports in Central America, South America, Mexico and California.

Others sail only a partial transit, entering the locks from the Atlantic and cruising into Lake Gatun before turning around and exiting again. These itineraries, sailing round-trip from Florida ports, combine the canal experience with island hopping in the Caribbean.

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The array of options means that a Panama Canal cruise experience is possible even if you’re short on time or have a limited budget — and chances are high that your favorite cruise line offers one or more itineraries. Most sailings attract couples, typically retirees, but if the timing is right, a Panama Canal cruise can also be a great multigenerational experience.

Here are a dozen of the best Panama Canal cruises to consider.

Holland America’s 14- to 17-night Panama Canal cruises

Holland America offers a variety of Panama Canal cruises, but the most popular itineraries span 14 to 17 nights. They offer a full transit between Fort Lauderdale or Miami and San Diego, Seattle or Vancouver, British Columbia, or vice versa, and are offered on multiple ships, including Koningsdam, Zuiderdam, Zaandam, Eurodam and Nieuw Amsterdam.

These sailings call on Cartagena, Colombia; Puntarenas, Costa Rica; Puerto Quetzal, Guatemala; and Huatulco and Puerto Vallarta or Cabo San Lucas, Mexico. Longer sailings also call on several Caribbean islands.

Who should go: Holland America ships sailing a full transit are popular with retired couples who appreciate the cruise line’s consistency and good value. All four ships accommodate between 1,432 and 2,650 passengers and offer signature onboard experiences that include the Greenhouse Spa and the World Stage for evening production shows.

The larger Eurodam, Koningsdam and Nieuw Amsterdam feature additional specialty dining options, such as Tamarind and Nami Sushi, as well as popular music venues B.B. King’s Blues Club and Billboard Onboard.

Regent Seven Seas Cruises’ 16-night Los Angeles-to-Miami cruise

Regent Seven Seas Cruises‘ newest ship, Seven Seas Grandeur, debuted in November 2023 and will transit the Panama Canal on several occasions in the next few years. The 16-night Los Angeles-to-Miami (Jan. 8-23, 2025) transit offers luxurious all-inclusive pampering, plus port calls in Ensenada, Cabo San Lucas and Acapulco, Mexico; Puerto Quetzal, Guatemala; Corinto, Nicaragua; Panama City; Cartagena, Colombia; and George Town, Grand Cayman.

Plan even further ahead for Grandeur’s 22-night Miami-to-Los Angeles transit (Jan. 3-25, 2026) to enjoy additional Caribbean ports of call. From Jan. 25 to Feb. 9, 2026, the ship will sail a 16-night Panama Canal transit from Los Angeles to Miami with an itinerary similar to the 2025 cruises.

Who should go: This itinerary can be a wonderful splurge for a couple seeking to celebrate a milestone anniversary or birthday in a memorable way on a luxurious new ship. Prices start at a hefty $10,099 per person for a spacious balcony suite, but they also include airfare, transfers, gratuities, dining and beverages, Wi-Fi, and shore excursions — meaning you’ll hardly have any other vacation expenses.

Related: The best luxury cruise lines for elegance and exclusivity

Celebrity Cruises’ 11-night Panama Canal & Southern Caribbean cruise

For a Panama Canal experience that begins and ends in Fort Lauderdale, Celebrity Cruises‘ 11-night Panama Canal & Southern Caribbean itinerary is a great option. At the time of writing, cabins are still available for the Dec. 2, 2024, cruise or the half dozen almost identical sailings that follow through April 2025.

All sailings are aboard the 3,260-passenger Celebrity Beyond and visit Cartagena, Colombia; Colon, Panama; Oranjestad, Aruba; Kralendjik, Bonaire; and George Town, Grand Cayman (Willemstad, Curacao, replaces Grand Cayman on some 2025 sailings).

Who should go: Celebrity Beyond and its Edge Class series sister ships appeal to millennials, Gen Xers and young-at-heart baby boomers who appreciate innovative design, entertainment and dining options. The ships are geared toward couples or groups of friends, but families with older teens might also enjoy the onboard vibe. There are no splash pools or waterslides for younger kids, although calls on three Caribbean islands offer aquatic fun.

Windstar Cruises’ 7-night Costa Rica & Panama Canal cruise

To explore the Panama Canal region in a relaxed manner aboard an intimate motorized sailing yacht or small ship, check out Windstar Cruises’ seven-night Costa Rica & Panama Canal itinerary. Bookable on more than a dozen dates from November 2024 through March 2026, the itinerary is offered aboard 148-passenger Wind Star or Wind Spirit (in 2024 and 2025) and 312-passenger Star Pride (in 2026).

The ship will travel from Colon, Panama, to Puerto Caldera, Costa Rica (or vice versa), transiting the canal. Passengers can visit Panama City and Isla Parida in Panama, plus Golfo Dolce and Quepos (for Manuel Antonio National Park) in Costa Rica.

Who should go: Fans of small-ship cruising who enjoy a casual onboard ambience, are interested in nature and wildlife, and wish to sample the regional flavors of Central America should consider a Windstar cruise. All accommodations on the sailing yachts are in snug yet well-designed cabins with windows but no balconies.

Wind Star and Wind Spirit are cozy and social four-deck ships, each featuring a pool and pool bar, a lounge, and two restaurants. Star Pride is the better option for those who prefer a more spacious, suitelike cabin with a balcony and a larger bathroom.

Related: Big vs. small cruise ships: Which will I like better?

Silversea’s 18-night Fort Lauderdale-to-Los Angeles cruise

Silversea Cruises‘ 18-night Fort Lauderdale-to-Los Angeles transit aboard 596-passenger Silver Moon offers a luxurious and leisurely way to experience the Panama Canal along with top ports in four countries and 10 sea days. The itinerary includes Cartagena, Colombia (where the ship overnights); Puntarenas, Costa Rica; Puerto Quetzal, Guatemala; and Puerto Vallarta and Cabo San Lucas, Mexico. The sailing takes place from April 1 to 19, 2025.

Silver Moon features the S.A.L.T. (Sea and Land Taste) program, which combines regionally inspired dining in S.A.L.T. Kitchen and cooking classes and demonstrations in S.A.L.T. Lab with culinary-inspired shore excursions.

Who should go: Silversea’s clientele is mostly mature couples with a luxury mindset and an appreciation for elevated dining with a strong regional focus. They also appreciate the cruise line’s all-inclusive ease. An almost three-week itinerary such as this is likely to attract retirees seeking an extended warm-weather escape.

Related: The best cruises for couples seeking romance and together time at sea

Carnival Cruise Line’s 8-night Panama Canal cruise from Tampa

Experiencing the Panama Canal doesn’t have to be time-consuming or budget-busting. Carnival Cruise Line‘s eight-night Panama Canal from Tampa itinerary offers a round-trip, partial-transit sailing aboard the 2,124-passenger Carnival Legend and Carnival Miracle. The ships call in Limon, Costa Rica, and George Town, Grand Cayman. Itineraries are available on a handful of dates in 2025 and 2026, and cruise fares begin at just over $1,000 per person.

With multiple pools (including the adults-only aft Serenity Pool), a WaterWorks aqua park, the Camp Ocean kids club and a wide array of restaurants, these ships offer enough diversions for sea-day fun, even at half the size of Carnival’s newest megaships.

Who should go: Carnival’s action-packed ships and affordable cruise fares appeal to families, friends and couples of all ages who enjoy a lively onboard ambience and casual complimentary dining options (including a Guy Fieri burger venue).

Related: The best cruise lines for families

Seabourn’s 34-night Caribbean Gems & Panama Canal cruise

For a one-way Panama Canal transit that visits 12 countries (St. Barts, Guadeloupe, Dominica, St. Kitts and Nevis, the British Virgin Islands, the Dominican Republic, Curacao, Colombia, Panama, Costa Rica, Guatemala, and Mexico) and offers 15 relaxing and luxurious days at sea, consider Seabourn‘s 34-night Caribbean Gems & Panama Canal cruise. The 450-guest Seabourn Sojourn will sail from Miami to Los Angeles, departing in November 2025.

You’ll enjoy beach time as you island-hop in the Caribbean, while calls on Golfito and Puntarenas in Costa Rica offer access to eco-adventure. Visits to Puerto Quetzal in Guatemala and Puerto Chiapas and Huatulco in Mexico feature excursions focused on pre-Spanish-colonial culture, coffee cultivation and more, while a call on Cabo San Lucas offers whale watching, deep-sea fishing or tequila tasting opportunities.

Who should go: Work-from-anywhere entrepreneurs and retirees who enjoy the luxury and refinement of small-ship cruising will enjoy this monthlong Panama Canal transit. Seabourn Sojourn pampers its guests with attentive service, elevated cuisine and all-ocean-facing suites featuring walk-in closets and spacious marble bathrooms. Seabourn’s all-inclusive cruise fares also cover gratuities and complimentary wines and spirits.

Princess Cruises’ 12-night Panama Canal with Costa Rica & Caribbean cruise

While Princess Cruises offers several longer ocean-to-ocean Panama Canal itineraries, its popular 12-night Panama Canal with Costa Rica and Caribbean cruises conveniently sail round-trip from Fort Lauderdale on more than 20 dates in 2024, 2025 and 2026.

What’s more, you can choose between two ships: the 3,140-guest Caribbean Princess and the 3,080-guest Emerald Princess. In addition to the partial transit, these sailings call on several Caribbean islands, including Aruba, Curacao, Jamaica and Grand Cayman, as well as Cartagena, Columbia; Limon, Costa Rica; and Colon, Panama.

Who should go: Couples who enjoy a ship with a more traditional vibe and families with kids who are content to participate in interactive learning activities and nature-based adventure (versus waterslides) will enjoy this cruise. Princess ships are known for their Movies Under the Stars screenings, multiple pools, specialty dining options, such as Sabatini’s Italian Trattoria and The Salty Dog Gastropub, and Crooners piano bar.

Related: The best destinations you can visit on a Princess Cruises ship

Norwegian Cruise Line’s 12-night South America: Peru, Colombia & Ecuador cruise

There’s no “Panama Canal” in this itinerary’s name, but Norwegian Cruise Line‘s 12-night South America: Peru, Colombia & Ecuador cruise (Feb. 27-March 11, 2026) makes a full canal transit as it sails from Miami to Lima, Peru. The 2,402-passenger Norwegian Jade will visit historic Santa Marta and Cartagena in Colombia; Panama City; Manta, Ecuador; and Trujillo and Lima in Peru.

Who should go: Couples and friends interested in experiencing not just a Panama Canal transit but some of the top coastal experiences along the Pacific coast of South America should choose this itinerary.

Norwegian Jade is an older, smaller vessel that was refurbished in 2022 and features a top deck more conducive to sunning than thrill rides. The ship also has a surprising number of restaurants for its size: two main dining rooms, a buffet restaurant, a pub-style bar and grill, an Asian restaurant, and an outdoor grill on a complimentary basis, plus six specialty dining venues (including a steakhouse and venues showcasing French, Italian and Japanese cuisines) for an added fee.

Oceania’s 16-night Miami-to-Los Angeles cruise

Oceania Cruises‘ 1,200-passenger Vista — which debuted in May 2023 as the first new-build ship in Oceania’s fleet in more than a decade — will offer back-to-back, 16-night Miami-to-Los Angeles (Jan. 8-24, 2025) and Los Angeles-to-Miami (Jan. 24-Feb. 9, 2025) itineraries.

Both sailings visit six countries with port calls that include George Town, Grand Cayman; Cartagena, Colombia; Puntarenas, Costa Rica; Corinto, Nicaragua; Puerto Quetzal, Guatemala; and Acapulco, Cabo San Lucas and Ensenada, Mexico. (The second sailing visits San Diego instead of Ensenada.)

Who should go: Oceania’s newest ship offers a great compromise between a small and medium vessel. It’s ideal for those seeking a premium cruise experience with casual sophistication.

Older couples especially will appreciate the ship’s elegant cabin decor in soft hues of wheat and seagrass, a mix of grand and intimate spaces, and a wide array of dining options. (Two new and noteworthy venues on Vista include Ember for inventive American cuisine and Aquamar Kitchen for wellness-focused breakfast, lunch and dinner.) A more immersive mixology program features curated cocktail menus, indulgent pairing experiences and specialty beverage carts.

Related: The best destinations you can visit on an Oceania Cruises ship

Cunard’s 26-night Southampton-to-San Francisco cruise

Cunard’s brand-new 2,996-passenger ship Queen Anne, which debuted in May 2024, will make both its first transatlantic crossing and its first Panama Canal transit on this historic 26-night Southampton-to-San Francisco sailing (Jan. 9-Feb. 4, 2025). The ship will first cross the Atlantic and then overnight in New York before calling on Aruba, transiting the canal and visiting Puerto Quetzal, Guatemala, and Cabo San Lucas, Mexico. It will conclude with an overnight in San Francisco.

The winter transatlantic crossing might not be right for everyone, but the second half of this voyage explores warm-weather destinations with plenty of relaxing sea days for sunning, reading, taking dance lessons and enjoying expert lectures.

Who should go: British cruise line Cunard appeals mainly to older travelers who savor the line’s formal traditions. This cruise is for you if you enjoy afternoon tea, dressing up for dinner, gala evenings and dancing to big-band orchestras. This particular itinerary appeals to retirees who wish to visit several cruise regions in one sailing.

Viking’s 180-day World Voyage

For the ultimate cruise indulgence, Viking’s 180-day World Voyage I includes a Panama Canal transit (on Christmas Day, no less) as 930-passenger Viking Sky cruises from Fort Lauderdale to New York City (Dec. 19, 2024-June 17, 2025). This round-the-world cruise will visit 37 countries while guests enjoy Viking Sky’s modern Scandinavian interior decor, soothing LivNordic Spa, two pools (including one with a retractable roof) and six onboard restaurants. Pricing includes airfare, gratuities, and complimentary wine and beer with lunch and dinner.

If this longer voyage is sold out, consider the 138-day Viking World Cruise (departing Dec. 19, 2025), also on Viking Sky. This sailing, which travels from Fort Lauderdale to London (Greenwich), visits 28 countries and transits the Panama Canal on the eighth day.

Who should go: With cruise fares that start at $79,995 and $59,995 per person, respectively, these extended adventures at sea require a luxury budget. Viking‘s base clientele is mostly retired or close-to-retirement-age professionals who enjoy the cruise line’s focus on educational enrichment (via onboard lectures) and serene ambience (there’s no casino, and the nighttime vibe is on the quiet side).

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